Vitamin D effects explored

A report from researchers in China concludes that vitamin D deficiency may play a significant role in autism spectrum disorders (ASD), while vitamin D supplementation may help to reduce ASD symptoms.

Yuwei Jiang and colleagues conducted an “umbrella” evaluation—that is, an overall review of previous reviews and meta-analyses—to evaluate the effects of vitamin D on autism risk and core symptoms of individuals with ASD. Analyzing data from nine reviews and meta-analyses, the researchers conclude, “The aggregated data suggest that vitamin D deficiency during early life may contribute to the risk of developing ASD, while experimental findings reveal that vitamin D supplementation might improve
core ASD symptoms.” They add, “Further research should explore whether high-dose vitamin D supplementation in early pregnancy could serve as a preventative measure against ASD.”

The researchers caution, however, “While the reviewed studies converge on the theme of vitamin D supplementation in ASD, they diverge in aspects such as additional treatments, dosage levels, and treatment durations, complicating the consistency of the findings. Additionally, the long-term effects of vitamin D therapy on ASD are yet to be determined.”

Citations

“Associations between vitamin D and core symptoms in ASD: An umbrella review,” Yuwei Jiang, Wenjun Dang, Lirong Sui, Tianci Gao, Xiangying Kong, Jin Guo, Shuang Liu, Hong Nie, and Zhimei Jiang, Nutrition and Dietary Supplements, July 9, 2024 (free online). Address: Zhimei Jiang, [email protected].