Scurvy a risk for children with ASD, restricted diets

A recent research review indicates that children with autism spectrum disorders (ASD) and restricted diets are at risk for scurvy, a disease caused by vitamin C deficiency. Symptoms of scurvy include gum disease, easy bleeding, weakness, and fatigue. 

William Sharp and colleagues searched medical databases for case reports of children diagnosed with both ASD and scurvy. Cases of scurvy due to issues other than dietary restriction were excluded. 

The researchers identified 20 case reports involving 24 children. They note, “The eventual diagnosis of scurvy followed a wide range of negative diagnostic testing; treatment with ascorbic acid [vitamin C] or a multivitamin resulted in rapid improvement.” 

The researchers say, “Symptoms of scurvy mimic other pediatric conditions (e.g., cancer). The range of diagnostic testing increased costs and healthcare risks (radiation, sedation) and delayed the diagnosis of scurvy. In children with ASD and severe food selectivity, a nutrition evaluation and laboratory testing are warranted before a more elaborate testing.”

Citations

“Scurvy as a sequela of avoidant-restrictive food intake disorder in autism: a systematic review,” W. G. Sharp, R. C. Berry, L. Burrell, L. Scahill, and B. O. McElhanon, Journal of Developmental and Behavioral Pediatrics, February 10, 2020 (epub prior to print publication). Address: William G. Sharp, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, [email protected].