A quarterly publication of the Autism Research Institute

The Autism Research Review International is quarterly publication of the Autism Research Institute

Fall, 2020 | Number 4, Volume 34

Vitamin D supplementation may be beneficial in ASD

Giving vitamin D supplements to children with autism spectrum disorders (ASD) may improve their symptoms, according to a new study from Iran. 

Zohreh Javadfar and colleagues enrolled 43 children with ASD in the study. The researchers administered vitamin D drops (from 300 IU/kilogram up to 6000 IU/kilogram daily) to approximately half of the group for 15 weeks, while the other half received a placebo. 

The researchers evaluated the children’s behavior before and after supplementation using the Childhood Autism Rating Scale (CARS), the Autism Treatment Assessment Checklist (ATEC), and the Aberrant Behavior Checklist-Community (ABC-C). Because vitamin D helps regulate levels of serotonin, which are altered in autism, the researchers also measured the children’s serum levels of serotonin at the beginning and end of the study. In addition, because vitamin D is anti-inflammatory and autism may be associated with elevated levels of proinflammatory cytokines such as interleukin-6 (IL-6), the researchers measured serum IL-6 levels before and after treatment. 

At the beginning of the study, more than 86% of the children had a vitamin D deficiency. By the end of the study, however, serum levels of vitamin D had increased significantly in the group getting the vitamin D drops. Scores on both the CARS and ATEC scales improved significantly in this group, and the researchers say that “nearly all symptoms relating to neurodevelopmental defects… were significantly improved following vitamin D supplementation.” However, there was no change in the children’s levels of serotonin or IL-6, and no change on the ABC-C. 

The researchers conclude, “These findings suggest that vitamin D supplementation may improve ASD symptoms; however, more studies with longer duration are indispensable to confirm our results.”


“Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: a randomized clinical trial,” Zohreh Javadfar, Hadi Abdollahzad, Jalal Moludi, Shahab Rezaeian, Houshang Amirian, Ali Akbar Foroughi, Seyed Mostafa Nachvak, Nasrin Goharmehr, and Roghayeh Mostafai, Nutrition, Vol. 79-80, November-December 2020 (online). Address: Corresponding author: Dr. Hadi Abdollahzad, Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran, [email protected].